Summary

• Kenan Thompson and Kel Mitchell are a comedic duo who have worked together on shows like All That and Kenan & Kel, bringing their hilarious sense of humor and chemistry to the screen.
• Alan Tudyk and Nathan Fillion have a longstanding working relationship, having appeared in shows like Firefly, Con Man, and The Rookie. Their onscreen collaborations have proven successful and enjoyable for viewers.
• Jennifer Aniston and Reese Witherspoon, who previously worked together on Friends, have a unique chemistry that shines through in their performances on The Morning Show, where they play the roles of newscasters.

A TV show is made even more special when actors who have worked together before reunite on a new project. TV shows often feature dynamic duos that have great chemistry and are a match made in TV heaven. However, that doesn't mean that every actor who has worked together on more than one TV show is part of a dynamic duo. Sometimes, actors can work together on a show but don't exactly come as a package deal. Actors who have worked together before usually have an established working relationship and a familiarity between them that results in a seamless collaboration.

For instance, William Shatner and Leonard Nimoy worked together on The Man From Uncle before reuniting in Star Trek. Their on-screen dynamic as Captain Kirk and Mr Spock was integral in making the series a success. During its run time, Friends often featured several actors as guest stars. Reese Witherspoon had been featured as a guest star on Friends where she played the role of Rachel's sister, Jill Green. Several years later, Witherspoon and Aniston worked together again on The Morning Show.

8 Kennan Thompson And Kel Mitchell

Worked Together On All That And Kenan & Kel

Kenan Thompson and Kel Mitchell first worked together on a Nickelodeon comedy sketch called All That. All That had a similar storyline to Saturday Night Live, except it was watered down to suit the younger audience for whom it was meant for. Kenan Thompson and Kel Mitchell saved as hosts on the show. The two later went on to star in a spinoff show of All That called Kenan & Kel. In Kenan & Kel, Thompson and Mitchell took on the role of best friends, Kenan Rockmore and Kel Kimble. The show followed the mischievous duo as they embarked on a series of misadventures.

Thompson and Mitchell as individuals are hilarious. When paired together, their combined sense of humor and onscreen chemistry makes them one of the best duos on TV. The two have also worked together in several movies, including, Good Burger, The Adventures of Rocky and Bullwinkle, and Two Heads Are Better Than None. Kenan Thompson and Kel Mitchell will be teaming up again in the movie Good Burger 2.

7 Alan Tudyk And Nathan Fillion

Worked Together On Firefly, Con Man, And The Rookie

Alan Tudyk and Nathan Fillion are no strangers to working together on different TV shows. They initially worked together on the short-lived space Western drama, Firefly, where Fillion took on the role of Captain Malcom Reynolds and Tudyk played the role of the pilot, Hoban "Wash" Washburne. Thirteen years after the end of Firefly, Tudyk and Fillion reunited on a TV show called Con Man which follows the life of a frustrated actor Wray Nerely (Tudyk) and his A-list movie star friend, Jack Moore (Fillion).

The two actors also appeared in the ABC police drama, The Rookie. In the TV shows Firefly and Con Man, Tudyk and Fillion worked together for most of the shows' duration. However, on The Rookie, Tudyk only appeared in seasons 2 and 4 for an episode each, where he played the role of the titular character, Ellroy Basso. Fillion, however, has been part of The Rookie since it's inception and is still starring as John Nolan.

6 Mayim Bialik And John Galecki

Worked Together On Blossom And The Big Bang Theory

Before working on the hit sitcom The Big Bang Theory, Mayim Bialik and John Galecki had worked together previously on a 1990 sitcom, Blossom. In Blossom, Bialik was one of the main characters, Blossom Russo while Galecki had a guest appearance as Jason in season 1's episode "Sex, Lies, and Teenagers". The two worked together again on The Big Bang Theory where Bialik took on the role of a neuroscientist and long-suffering girlfriend (later to be wife) of Sheldon Cooper, Amy Fowler. In The Big Bang Theory, Galecki played the role of Sheldon's best friend, Leonard Hofstadter.

Related: 15 Greatest TV Duos Ever, Ranked

5 Jennifer Love Hewitt And Greg Grunberg

Worked Together On Love Bites, The Client List, And Criminal Minds

Jennifer Love Hewitt and Greg Grunberg first worked together on the romantic comedy-drama, Love Bites. In Love Bites, Hewitt appeared as a guest star where she played herself, and Grunberg took on the role of one of the main characters on the show, Judd Rouchser. They later reunited in the series, The Client List, where Hewitt was the main character Riley Parks, and Grunberg had a recurring role as Dale Locklin. Hewitt and Grunberg ed the cast of Criminal Minds in season 10 of the show. The two played the role of a married couple, Kate and Chris Callahan.

4 Wentworth Miller And Dominic Purcell

Worked Together On Prison Break, The Flash, DC's Legends of Tomorrow, And Prison Break Revival

Wentworth Miller and Dominic Purcell have one of the longest working TV relationships that spans over 12 years. Miller and Purcell first worked together on the action drama Prison Break, where they played the roles of two brothers, Michael Scofield and Lincoln Burrows, respectively. In 2014, Miller had a guest star role as Captain Cold in The Flash. He suggested that Purcell him on the show as Heat Wave, which ended up with the two actors working together on The Flash spinoff, DC's Legends of Tomorrow. Miller and Purcell worked together again on Prison Break season 5, a revival of the original series, which many fans felt was a mistake.

Related: 10 Great Movie Duos Who Only Worked Together Once

3 Tyler Hoechlin And Ian Bohen

Worked Together On Teen Wolf And Superman & Lois

Ian Bohen is known for taking on roles of complex villains. Tyler Hoechlin and Bohen first worked together on Teen Wolf. Hoechlin took on the role of the dangerous werewolf, Derek Hale and Bohen played Derek's uncle, the alpha of the pack, Peter Hale. In Teen Wolf, Derek killed Peter so he could be the alpha, but that wasn't the last time the pair would be seen working together. The two later went on to work on opposite sides in Superman & Lois. In Superman & Lois, Bohen was in his element as the villain, Lieutenant Mitch Anderson, while Hoechlin played the Man of Steel, Clark Kent.

2 Jennifer Aniston And Reese Witherspoon

Worked Together On Friends And The Morning Show

Before working together on Apple TV's hit series, The Morning Show, Jennifer Aniston and Reese Witherspoon had first worked together on Friends. Witherspoon appeared as a guest star on the popular sitcom where she played Rachel's sister, Jill Green. After working together on Friends, Aniston and Witherspoon reunited on the 2019 drama, The Morning Show. This time, the pair played the roles of newscasters, Alex Levy and Bradley Jackson, respectively. Aniston and Witherspoon have a unique chemistry that shines through whenever they are on screen together.

Related: 10 Acting Duos With Surprisingly Good Chemistry

1 William Shatner And Leonard Nimoy

Worked Together On The Man From Uncle, T.J. Hooker, Star Trek, And Star Trek The Animated Series

William Shatner and Leonard Nimoy are one of the reasons that made Star Trek great. Prior to starring on Star Trek, Shatner and Nimoy worked together on an episode of the series The Man From Uncle titled "The Project Strigas Affairs." The two later reunited in Star Trek and Star Trek: The Animated Series with Shatner playing iral James T. Kirk, and Nimoy as Mr. Spock. Shatner and Nimoy worked together on a TV series for the last time in the police drama, T.J Hooker. Nimoy and Shatner will go down in history as having one of the best collaborations on TV shows.

William Shatner wrote a Memoir, Leonard: My Fifty-Year Friendship With A Remarkable Man, about his friendship with Leornard Nimoy.