Netflix's Big Mouth season 8 handles all the gross and uncomfortable topics related to puberty and sex with continued nuance and hilarity.

Big Mouth season 8 is a fitting send-off to one of the best shows on Netflix, and its cast had a big part in making it work. Every season of Big Mouth has featured some truly impressive guest stars - most of the main cast is comprised of wildly popular comedians and actors - and season 8 is no different. From acclaimed comedians to rising dramatic stars in Hollywood, Big Mouth season 8 has attracted more than a few notable names. Here's what you need to know about who's who in Big Mouth season 8.

Nick Kroll as Nick, Lola, Maury, Coach Steve, Rick, & More

Date of Birth: June 5, 1978

• Active Since: 2004

Actor: Nick Kroll was born in New York City, New York. Kroll had his breakthrough role in 2009 when he began playing Ruxin on The League. Since then, Kroll has become something of a titan of comedy. In addition to co-creating and starring in Big Mouth, Kroll has appeared in countless comedy shows and movies, dozens of animated vocal roles, a handful of comedy specials, and even his own sketch comedy show, Kroll Show. Kroll has gained a reputation for his often crass sense of humor and his incredibly busy schedule: he had eight different credits in 2024 alone, while he was writing Big Mouth season 8.

Character: Nick Kroll voices a wide assortment of characters in Big Mouth season 8. He voices Nick Birch, the self-centered and often insecure protagonist of the show. He also voices Maury, the main hormone monster for various characters, Lola, a boisterous girl with no boundaries, Coach Steve, the odd gym teacher at the kids' school, and Rick, the elderly and strange hormone monster.

John Mulaney as Andrew Glouberman

Date of Birth: August 26, 1982

• Active Since: 2008

Actor: John Mulaney was born in Chicago, Illinois. Mulaney had his breakthrough role in two parts: first, as a staff writer for Saturday Night Live, then through his stand-up comedy specials like Kid Gorgeous at Radio City Music Hall. Mulaney has continued to pursue stand-up comedy throughout his career, but he's also turned to scripted comedic roles in movies like Spider-Man: Into the Spider-Verse, where he voiced Spider-Ham, and shows like The Bear, where he played Stevie, and Poker Face, where he played Daniel Clyde-Otis.

Character: John Mulaney voices Andrew Glouberman in Big Mouth season 8. A long-standing pillar of the show, Andrew is Nick's on-again-off-again best friend, and the two often get into drama due to their pubescent hormones.

Jessi Klein as Jessi Glaser

Date of Birth: August 17, 1975

• Active Since: 2005

Actor: Jessi Klein was born in New York City, New York. Klein had her breakthrough role in 2009 when she both wrote and starred in Michael & Michael Have Issues. Klein is best known as a writer and producer, however, as she's worked on various successful shows like Inside Amy Schumer, Saturday Night Live, and Dead to Me.

Character: Jessi Klein voices Jessi Glaser in Big Mouth season 8. Another pillar of the show, Jessi is a friend of Nick, Andrew, and Missy, though she sometimes grows distant from them due to her own troubles during puberty.

Jason Mantzoukas as Jay Bilzerian

Date of Birth: December 18, 1972

• Active Since: 2000

Actor: Jason Mantzoukas was born in Nahant, Massachusetts. Mantzoukas had his breakthrough role in 2010, when he began playing Rafi in The League opposite his Big Mouth co-star, Nick Kroll. Since then, Mantzoukas has been acting almost constantly in both animated and live-action shows and movies. Some of his more notable recurring roles came on shows like Parks and Recreation, Brooklyn 99, and Invincible as Rex Splode.

Character: Jason Mantzoukas plays Jay Bilzerian in Big Mouth season 8. Jay is another member of the core group of friends alongside Nick, Andrew, Jessi, and Missy.

Ayo Edebiri as Missy Foreman-Greenwald

Date of Birth: October 3, 1995

• Active Since: 2014

Actor: Ayo Edebiri was born in Boston, Massachusetts. Edebiri had her breakthrough role in FX's The Bear, where she plays sous-chef Sydney Adamu. Edebiri has had a huge spike in popularity since that 2022 role, and she's become an international sensation. From voice acting roles in movies like Inside Out 2 and Spider-Man: Across the Spider-Verse to starring roles in live-action movies like Opus, Edebiri has become one of the biggest rising stars in Hollywood (and Ireland).

Character: Ayo Edebiri voices Missy Foreman-Greenwald in Big Mouth season 8. Edebiri took over the role in season 4, after previous voice actor Jenny Slate felt uncomfortable voicing a Black character. Missy is a nerdy biracial girl who has to explore her heritage while also learning about puberty like the rest of the characters in Big Mouth.

Big Mouth Season 8 ing Cast & Characters

Maya Rudolph as Connie Cassienga: Maya Rudolph voices Connie in Big Mouth season 8. Connie is a female hormone monster and a colleague of Maury who advises characters like Jessi. Rudolph is best known for movies like Bridesmaids and The Way Way Back.

Fred Armisen as Elliot Birch: Fred Armisen voices Elliot Birch in Big Mouth season 8. Elliot is Nick's father who is quite out of touch with his son. Armisen is known for shows like Portlandia and movies like Easy A.

Jordan Peele as Duke Ellington & Cyrus Foreman-Greenwald: Jordan Peele voices both the ghost of Duke Ellington and Cyrus Foreman-Greenwald in Big Mouth season 8. Duke Ellington haunts Nick's attic, while Cyrus is Missy's father. Peele is known for Key & Peele and for directing horror movies such as Get Out and Nope.

Big Mouth Season 8 Cameos

Cynthia Erivo as Gynecologist: Cynthia Erivo voices a gynecologist in Big Mouth season 8. Erivo is known for playing Elphaba in Wicked and Harriet in Harriet.

Quinta Brunson as Quinta: Quinta Brunson is best known for playing Janine Teagues in Abbott Elementary. Brunson has been playing Quinta on Big Mouth since 2019.

Holly Hunter: Holly Hunter is known for movies like Broadcast News and The Incredibles, where she voiced Helen Parr.

Steve Buscemi as Mr. Pink: Steve Buscemi voices Mr. Pink in Big Mouth season 8. Mr. Pink is a cat who convinces Andrew to meddle in his relationship with Nick. Buscemi is known for shows like Boardwalk Empire and movies like Fargo and Reservoir Dogs, where he also played a character named Mr. Pink.

Kristen Wiig: Kristen Wiig is known for having a long-running role as a cast member on Saturday Night Live and for starring in Bridesmaids opposite Maya Rudolph.

Nathan Fillion: Nathan Fillion is known for shows like The Rookie and Firefly.

Ali Wong: Ali Wong is known for her stand-up comedy career and for playing Amy Lau in Beef opposite Steven Yeun.

Keke Palmer: Keke Palmer is known for playing Dreux in One of Them Days and Emerald Haywood in Nope, which was directed by Jordan Peele.

Natasha Lyonne as Ms. Dunn: Natasha Lyonne voices Ms. Dunn in Big Mouth season 8. Ms. Dunn is the school's health teacher. Lyonne is known for movies like But I'm a Cheerleader and shows like Poker Face, where she had an episode with both John Mulaney and Cynthia Erivo.