The deadly disease known as Dragonsplague in Dragon's Dogma 2 can bring devastating calamity if you don't find a cure for the Pawns who contract this illness. Your allies who gain this affliction are a risk to themselves and every other Pawn who could become infected. Recognizing the symptoms of Dragonsplague early can be the key to avoiding the ruination of entire settlements during your adventure.

Dragonsplague is something mentioned the first time you interact with any Pawn in Dragon's Dogma 2. This warning tells you that any Pawn can mysteriously contract the disease out of nowhere, to the point where it is unrecognizable even while checking the Status of that NPC. However, the consequences of Dragonsplague are never mentioned, with a "devastating calamity" being the only effect of the illness' persistence.

How To Identify Dragonsplague In Dragon's Dogma 2

The Dragonsplague disease can only be contracted by Pawn allies and is shown through glowing red eyes on characters who've become infected. Your Arisen character is unable to get Dragonsplague, but any Pawn you recruit to your party has a chance to grow ill. Some early signs besides the red eyes might be coughing, spitting, or the Pawn having intense migraines when standing idle.

Be careful not to diagnose Pawns with naturally red eyes as having Dragonsplauge. Some NPC creations recruited from The Rift are simply designed to have crimson pupils or features that may resemble the disease's progression.

An easy solution to a Pawn's Dragonsplague is to dismiss them from your group, even if you are not certain whether they have the disease or not. It's better to be safe than sorry, especially when you have the chance to avoid Dragonsplague in Dragon's Dogma 2 entirely. This is not a cure to the problem though, as some of your other Pawns may have been infected even if you dismissed the culprit NPC ahead of time.

How To Cure Dragonsplague In Dragon's Dogma 2

Unfortunately, there are no known cures for Dragonsplague besides killing the Pawn who has it before it can spread to other allies in Dragon's Dogma 2. Another solution is to allow an infected Pawn to the disease on to someone else. This causes the original holder of the illness to be "cured," but it still creates the problem of someone else you know contracting the illness instead.

Letting Dragonsplague build will cause every NPC in a settlement to die overnight after a cutscene plays when the infected Pawn rests at an inn. While resting at a campsite doesn't cause this, you could easily wipe out a whole town by accident when staying somewhere in a populated area with a Dragonsplague-affected Pawn. Even if you have a way to revive people who perished, there will be too many dead for you to bring back.

Main story and side quest characters in Dragon's Dogma 2's huge map could die from the calamity wrought by Dragonsplague, preventing you from earning rewards or even pursuing missions tied to key NPCs.

There are a few ways you could lead an infected Pawn to their death, including letting them perish while fighting a large monster or just throwing them into some deep water. No matter how you do this, the only real solution is to part ways with a Pawn or put them out of their misery. This may not be the cure for Dragonsplague in Dragon's Dogma 2 you may have been looking for, but it is far better than the alternative.