The these cleverly designed covers, the best match-up is with a character that's not on any of them.
Kraven the Hunter is a villain that goes way back to the original run of Amazing Spider-Man comics. First appearing in The Amazing Spider-Man #15 from Stan Lee and Steve Ditko, he's become part of the web-slinger's most recognizable villains in his rogue's gallery. He was a founding member of the infamous Sinister Six and has occasionally bested Spider-Man on various occasions. The popular character was even resurrected in 2009 following his original death in Kraven's Last Hunt to bring him into modern times. Kraven is a villain that has stood the test of time...but placing him against the Predator would be a battle to as it would answer the question of who the Galaxy's Deadliest Hunter truly is.
At the beginning of the fight, it may seem clear who the victor will be. Kraven appears to just be an average man while the Predator is equipped with advanced tech to keep themselves hidden and primed for hunting. Appearances can be deceiving though. Kraven actually has superhuman abilities given to him by a potion that he ingests, which not only give him strength and durability but also enhanced senses. One of the Predator's biggest features is cloaking so they can get the drop on their prey while sneakily maneuvering through the trees. This is something that they would never be able to do against Kraven though because the potion gives him enhanced sight, hearing and smell. The element of surprise would be out of play because Kraven would hear the Predator coming and would likely be able to see the changes in the environment.
Since the option to stealth is out, this would mean Kraven would likely get sliced at by the Predator's wrist blades and get punched a few times, but his durability would prevent his death as he can withstand more blows than any human can.
When all is said and done, Kraven would likely be declared the winner by the metaphorical referee. He just has too many advantages in his favor to rid the Predator of their greatest strength: stealth. Once that's gone, it's just a matter of time before they fall, and a new Galaxy's Deadliest Hunter is declared. In the end, Kraven the Hunter would make history as he manages to take down the Predator and cement himself as one of Marvel's most formidable foes.
