Warning: SPOILERS for Loki episode 6, "For All Time. Always."
The He Who Remains (Jonathan Majors) as the being who created the organization. His debut, as well as the events that followed after his death, will have significant ramifications in the universe moving forward.
When Marvel Studios kicked off Phase 4 with safeguards the Sacred Timeline in order to prevent a new multiversal war by pruning wayward variants and resetting Nexus events.
As hard as the TVA worked to ensure that the Sacred Timeline remains untampered with, Loki and his female variant, Sylvie (Sophia di Martino), eventually unleashed the multiverse. Following a grueling journey to get to He Who Remains, Sylvie successfully accomplished her goal of taking down the being behind the TVA. Loki was reluctant to take out He Who Remains, already having experienced what happens when power is removed only to be replaced by something worse. But Sylvie, who was motivated by revenge and pain and anger, ignored He Who Remains' warnings about what would happen should he die and killed him anyway. The end of the Loki finale revealed countless timelines branching out, which now becomes the primary concern for the MCU's heroes from here on out.
Click here to watch Loki Just Set Up The Future Of The MCU on YouTube.
What If…?
In conjunction with producing live-action content for Disney+, Marvel Studios is releasing its first animated show, Loki's explanation about the multiverse, what goes down in What If...? could simply be deemed as incidents from other universes, with the possibility of spilling over to other realities.
Spider-Man: No Way Home
Marvel Studios and Sony have been mum about plot specifics for Spider-Man are also all but officially confirmed to return, with persistent rumors that Charlie Cox will also reprise his role as Matt Murdock from the Marvel Netflix shows.
This is backed up by Doctor Strange in the Multiverse of Madness. Now, the Loki finale has made all of this a greater possibility with various alternate timelines existing — all of them at risk of colliding with each other.
Doctor Strange in the Multiverse of Madness
Long before the setup, the title of Doctor Strange in the Multiverse of Madness already gave away the idea that the MCU would tackle the concept of the multiverse. The Sam Raimi-directed sequel has been confirmed to have narrative connections to WandaVision, Spider-Man: No Way Home, and Loki. But while there was an initial presumption that it would be Scarlet Witch who would kickstart the multiverse, it's the events of Loki that accomplished this storytelling task. Doctor Strange (Benedict Cumberbatch), who is responsible for protecting Earth from inter-dimensional threats like Dormammu, is now facing a bigger issue with various branches of time chaotically co-existing. Especially now that there's a risk of them crossing over with each other.
He Who Remains said it himself — while multiple realities once worked well for everyone involved, Kang the Conqueror changed that by causing a rift between alternate versions of himself. Doctor Strange's primary goal will be to ensure Earth's safety from any chaos that will ensue now that the multiverse has been unleashed, including from any other worse, more dangerous variants of Kang. Considering the fact that the God of Mischief was directly involved in this catastrophe, it also makes sense for Doctor Strange 2 as was recently reported.
Loki Season 2
Marvel Studios officially announced Kang the Conqueror, who could very well be a more ruthless version of He Who Remains.
Ant-Man and the Wasp: Quantumania
Majors was originally cast to play the villain Kang the Conqueror in Nathaniel Richards, a scientist in the comics who accidentally discovered alternate universes. How Kang the Conqueror comes into with Ant-Man (Paul Rudd), Wasp (Evangeline Lilly), Hank Pym (Michael Douglass), and Janet van Dyne (Michelle Pfeiffer) is still unknown, but it's worth noting that in the Quantum Realm, there's an outline of the city which might be the villain's Chronopolis.
Loki will return for season 2 on Disney+.