WARNING! SPOILERS FOR MAESTRO #1 BELOW
By today's standards, it would be difficult to take someone dressed like the Hulk appears to be trapped in a realistic illusion of a perfect life which is blamed on Mysterio, which itself may be a subtle reference to another time where Mysterio's illusions turned out too good to be true.
In Maestro #1 by Peter David, German Peralta, Dale Keown, Jesus Aburtov, and Jason Keith, the Hulk has accomplished the kind of balance he's sought for his entire life. Able to maintain his intelligence while in Hulk form, Dr. loving father alongside his wife Betty and his two children, Thaddeus and Rick. Everything is perfect until family dinner at the Avengers Mansion is interrupted by macabre warnings from his son and what appears to be computer glitches in the shape of his wife.
He is comforted by the Avengers will investigate the disturbance and yells at his wife when her conversation is starting to repeat herself. His attempt to leave to get some fresh air is confronted by the realization that his version of Mysterio has seriously upgraded his technological skills because everything that Hulk believes to be his perfect life is nothing more than an advanced simulation.
The inference about Mysterio taking over Hulk's mind and sense could be a subtle reference to his role in the villain takeover seen in the iconic Logan into actually slaughtering his fellow X-Men teammates by masking their scents. Without the X-Men, the Red Skull and other villains are able to take over the United States and kill most of the surviving heroes while the event leads to Logan retiring his Wolverine identity and taking a vow of non-violence. His involvement in this deliberate massacre would be later explored in the Old Man Logan series where that version of Logan sought to kill any individuals responsible in order to prevent his future from ever occurring which included fighting a version of Maestro from another timeline.
While the Hulk fought the imaginary Avengers and escaped the simulation to learn the truth, the blame and questioning of Mysterio and his abilities continue this idea that the hero is not to be taken seriously. He may have never taken over the world on his own but as a founding member of the Sinister Six or primary antagonist to Spider-Man or even Daredevil, Mysterio has proven it is not wise to underestimate him. Given the proper motivation and tools to make it happen, Quentin Beck can turn a happy story into a nightmare quicker than Bruce Banner can turn green. Although Mysterio was merely a convenient scapegoat for the imaginary Avengers to pin the crime on, unfortunately, it wasn't believable enough to save the world from Maestro's arrival.
