With Deadpool's MCU debut coming in 2024 with She-Hulk: Attorney At Law if the series continues. Deadpool has had his run-ins with the Hulk, and She-Hulk's skirmish with Daredevil sets up potential future clashes between herself and other heroes. Should the two meta-heroes ever clash, it would likely be an exciting, fourth-wall-breaking affair.
Deadpool has an arsenal of weaponry that would cut down and rip through most targets fairly easily, but She-Hulk is of a different breed. Her skin is nearly impenetrable, so normal weaponry of typical metals will be rendered useless. While it remains a huge problem for Deadpool, his healing factor helps level the playing field, allowing him to endure a long fight. If he manages to get She-Hulk to transform back into her human form, possibly by knocking her unconscious with one of his grenades, his chances of being victorious increase.
Why She-Hulk Would Beat Deadpool In A Fight
She-Hulk's control over her rage and ability to transform at will diminish the impact of Deadpool's attacks. If she manages to incapacitate him early in the fight, it'll be game over for Deadpool. His usual weapons put him at a disadvantage. However, in the comics, Deadpool's weapons also included not only mystical items which could potentially inflict more damage onto She-Hulk, but also adamantium blades. Judging from Wolverine's fights with the Hulk, adamantium is the only known metal capable of penetrating the Hulk's skin.
Unfortunately, Wolverine's Marvel story rarely saw him defeat the Hulk. Part of the reason for that is due to an increase in power Hulks get when their rage increases or they go berserk. This means that even if Deadpool managed to get his hands on an adamantium sword and give She-Hulk a few cuts to think about, if it enrages her, she can fight through the pain and deliver even more powerful attacks. Though Deadpool's healing factor is impressive, he's still human, and a strong enough Hulk Smash should take him out long enough for She-Hulk to capture him.
A She-Hulk Vs. Deadpool Fight Would Beat All Other Superhero Fights
Assuming this fight stays true to the characters, it will likely devolve into a battle of wits over fists, throwing jokes instead of punches. With Deadpool and She-Hulk breaking the fourth wall, and being aware of each other's ability to do so, it would be difficult for either to maintain any serious composure, making it a comical de-escalation. But that just may be the best part. Between Deadpool's color commentary and mocking of his targets, and She-Hulk's inquisitive curiosity and self-deprecating humor, the two can turn their fight onto the ones truly responsible for their problems--the writers.
Fed up with playing by their rules, they could even choose not to give the writers the satisfaction of seeing a fight. With She-Hulk's longing for love and Deadpool's grief over losing the love of his life, the two could bond over unfortunate accidents that turned them into who they are, their ability to break the fourth wall, as well as their lackluster love lives. Instead of a fight with She-Hulk and making Deadpool fly through the air, there could be romantic sparks flying; or both. Her developing relationship with Daredevil aside, She-Hulk's match with Deadpool could be the most comically anti-climatic fight turned meet-cute for the MCU.