Here's Helena Bonham Carter's tragic character arc on Collateral.
He followed up Thief with a project that's very much an outlier in his career, which was 1983's The Keep. This is a gothic horror movie adapted from the novel of the same name, but while Mann set out to make an "adult fairytale," it suffered various production woes and Paramount brutally cut it down following bad test screenings; Mann has all but disowned the final movie, which has since attained a cult following. He moved back to TV to serve as executive producer on Miami Vice in 1984, which became one of the biggest shows of its era.
Miami Vice followed undercover Miami cops Crockett (Don Johnson, Fight Club) earliest roles was a two-episode stint on Miami Vice season 3 as Dr. Theresa Lyons, Crockett's girlfriend.
Theresa is first introduced in the Miami Vice episode "Duty And Honor," but she later takes center stage in "Theresa." While Crockett is madly in love with Theresa and is even planning to propose, he's blissfully unaware she's also a secret drug addict. She became addicted to painkillers following an injury, but when Crockett starts investing her drug dealer, she's blackmailed into giving up the location of an evidence locker or they'll expose her habit. After the evidence is destroyed, Crockett traces her connection and confronts her about her secret addiction.
Theresa later tries to commit suicide but Tubbs finds her in time and she recovers in hospital. Instead of proposing marriage, the episode ends with Crockett insisting she head to a special treatment center to work on her addiction. That's the last time Theresa was seen on Miami Vice but while she hopefully did make a full recovery, her medical career would likely be over.