Warning! SPOILERS for Doctor Strange in the Multiverse of Madness.
Marvel Studios makes Kamala Khan's origin change in Doctor Strange in the Multiverse of Madness. Although comic readers know Kamala Khan to be an Inhuman in the comics with polymorphic powers, early marketing materials for the Ms. Marvel Disney+ show indicated that wouldn't be the case in the Marvel Cinematic Universe. Her stretchy size-changing powers have been replaced with energy constructs that seemingly come from mysterious bangles, connecting her to the cosmos potentially instead of Inhumans.
The MCU changing Ms. Marvel's origin to avoid the Inhumans in Phase 4 might not be ideal for everyone, but it did still make some sense given the current state of the shared universe. It allows Marvel Studios to push Kamala closer to Captain Marvel, who she'll team up with in The Marvels. Meanwhile, it also meant avoiding Ms. Marvel having any potential association with the failed Inhumans TV show. Marvel Studios hasn't made Inhumans part of the core universe either, so Kamala Khan's origin would have been the first time an Inhuman was properly brought to the MCU. However, the explanation for Ms. Marvel not being an Inhuman in the MCU just became even worse.
Thanks to the inclusion of Black Bolt in Doctor Strange in the Multiverse of Madness, Marvel Studios has proved that they weren't really afraid of drawing comparisons to the Inhumans TV show when it came to telling Kamala Khan's origin. The movie could have cast anyone to play the Inhumans leader, but Marvel deliberately chose to give Anson Mount another chance to play the part. Using a cast member from Inhumans and introducing the team in some form in Doctor Strange 2 means that the MCU now has laid the groundwork for Ms. Marvel to continue the story. Instead of doing this, though, the change to Ms. Marvel's origin will keep this from happening.
Now that Marvel Studios has teased a proper version of the Inhumans, the decision to change Ms. Marvel's origin becomes a bit more baffling. Ms. Marvel could have been a seamless continuation of the Inhumans story of Phase 4. Anson Mount's Black Bolt cameo alongside Doctor Strange 2's Illuminati would be able to act as a brief tease of who he is, what his powers are, and the Inhumans as a whole. This would then lead perfectly into Ms. Marvel showing Kamala Khan experience Terrigenesis. It would even make sense in that case for Iman Vellani's young Inhuman to meet Anson Mount's character, potentially even including a visit to Attilan and meeting other of the Inhumans Royal Family.
Black Bolt's appearance in Doctor Strange 2 further shows how odd it is that Marvel decided to change Kamala Khan's origin in this manner. The full story as told in Ms. Marvel could reveal additional information and leave the door open for an Inhumans connection down the road, but that doesn't appear to be the direction Kamala's MCU story is heading. Kevin Feige has said the change was due to Ms. Marvel's MCU future with Captain Marvel and to better fit the MCU, but Doctor Strange in the Multiverse of Madness including Black Bolt shows that Ms. Marvel could have kept a more comic-accurate origin and power set for Kamala Khan.