Summary

• Arceus, the god of Pokémon, possesses the power to exploit Mewtwo's weaknesses and deal low or zero damage to him.
• Mew, the original Pokémon from which Mewtwo was cloned, can defeat Mewtwo with its DNA that allows transformation into any living creature.
• Others like Rayquaza, Ho-Oh, and several other Legendaries have the potential to defeat Mewtwo in battle, but there are still many that are weaker than this powerful Gen 1 Pokémon.

The philosophy behind Mewtwo’s creation was to make the world’s strongest Pokémon. Since Mewtwo is a clone of Mew, there seemed to be only one Pokémon that could match him at the time of his original creation. However, Pokémon has vastly expanded its universe since Gen 1 to include more powerful Legendaries, Mythicals, and even Ultra Beasts. Some of these are even deities that can stand toe-to-toe with the lab-created powerhouse. Despite the power of Mewtwo, however, there are other Pokémon who are more powerful.

In the years since Mewtwo's first appearance, the Pokémon franchise has continued to come out with more games and memorable monsters. For example, the most recent Gen 9 games have introduced Paradox Pokémon and even Stellar-types that are incredibly powerful. These newcomers come equipped with new techniques and battle strategies that make them unique challengers for Mewtwo's reputation as one of the most powerful Pokémon in existence.

Arceus Is Stronger Than Mewtwo

Arceus' Type Changes Make Him A Formidable Foe

Not surprisingly, Arceus is one of the strongest Pokémon in existence. Being the god of all Pokémon (who also created the universe), Arceus has an incredibly impressive power level. Arceus excels in combat by taking advantage of type weaknesses, resistances, and immunities. With the capability to switch his type on the go, Arceus would be able to land the Bug-, Dark-, and Ghost-type attacks that Mewtwo is weak against. Mewtwo might be able to get in one or two hits, but Arceus' type changes would also mean that Mewtwo's attacks would hit at low or zero damage.

Mew Can Be Even More Powerful Than Mewtwo

Mew Has The DNA Of All Pokémon In Its Body

Mewtwo is a clone of Mew. While Mewtwo’s savagery and raw strength might give Mew a run for its money, this little Legendary from Gen 1 still manages to come out on top. During their battle in the first movie, for instance, Mew seemed to have fun the entire time they were fighting. This suggests that if Mew were going full force it wouldn’t be much of a competition. Furthermore, Mew has the DNA of all Pokémon inside its body, allowing it to transform into any other living creature - even if the games have yet to show off Mew's prowess in the way the movies have.

Rayquaza Is Stronger Than Mewtwo

Mega Evolution Makes Rayquaza Even More Powerful

The strongest Legendary in Hoen is perhaps one of the strongest Pokémon in all continuity. Rayquaza was already a serious threat to the Pokémon world, capable of fighting off Deoxys by itself and calming a war between Groudon and Kyogre. However, Gen 6's introduction of Mega Evolution has caused the Rayquaza from Omega Ruby and Alpha Sapphire to become a force of nature capable of blasting through meteors with ease. There’s no limit to the power of Rayquaza now, and Mewtwo would easily lose a fight with it.

Lore Suggests Ho-Oh Can Be More Powerful Than Mewtwo

Sacred Fire Gives Ho-Oh An Edge

Ho-Oh is one of the most heavily worshiped Pokémon in the Johto Region, and its world-shattering potential makes it easy to see why. Not only does this gracious bird leave a beautiful trail wherever it flies, bringing luck to those who simply gaze upon it, but it can even revive those who were deceased. That’s all without mentioning its powers, as its Sacred Fire attack ensures that no one would be able to fight against it. Its power over mortality means that Mewtwo would have a hard time defeating it within Pokémon's own lore, too.

Palkia Is More Powerful Than Mewtwo In Lore

This Gen 4 Pokémon Can Command Space Itself

Palkia is a deity with command over space. He can warp reality and send people to other dimensions. His battle with Dialga was so intense that the two of them had to be sent to their own dimension, so they wouldn’t harm the rest of the world in the process. Palkia’s powers as a dragon and its immense abilities mean that most wouldn’t be able to stand a chance against it. Darkrai tried to stop both Pokémon in one of the movies, but he was soon defeated by both, so it makes sense that Mewtwo would find a similar fate.

Like Palkia, Dialga Could Probably Defeat Mewtwo

Dialga Is Able To Control Time

Palkia and Dialga would probably both be able to beat Mewtwo on their own. Palkia with its control over space, and Dialga with its control over time. That feat alone would allow Dialga to mess with Mewtwo and manipulate its surroundings. Furthermore, if Mewtwo managed to get a single hit on Dialga, all it would have to do is reverse time to get the better of Mewtwo’s strategy. That’s all without mentioning just how hard Dialga hits each time it lands an attack.

Ogerpon Could Likely Defeat Mewtwo One-On-One

The Ability To Change Its Type Gives Ogerpon An Edge

Introduced in Scarlet and Violet's Teal Mask DLC, Ogerpon is a powerful new Pokémon that can change its type with the help of masks. It's ability to Terastalize also makes it extra powerful, and it would likely give it an edge of Mewtwo in combat. In of lore, Ogerpon is strong on its own, but its versatility is really what makes it stand out.

Calyrex Could Beat Mewtwo

Spectrier and Glastrier Help Give Calyrex An Advantage

Calyrex was once the king of the Galar region, and it's one of the few Pokémon capable of taking on Mewtwo in a fight. Calyrex' base form may be better designed for peace than combat, but this ruler has a few tools that make it a formidable opponent. First, Calyrex has the ability to see the past, present, and future. This means that Calyrex would see any of Mewtwo's plans coming before he could strike.

Additionally, this Pokémon can bond with the Ice-type Glastrier or the Ghost-type Spectrier. While with the former, the pair is capable of dropping the surrounding temperature below -500 degrees Fahrenheit. Spectrier allows Calyrex to bombard its area with life-force stealing spirit flames. Either of these would likely be too much for Mewtwo.

Kyogre Is Stronger Than Mewtwo

Primal Form Kyogre Gets Even More Powerful

Kyogre and Groudon each have power over sea and land, respectively. In their standard forms, it’s likely that Mewtwo would’ve been able to defeat them, considering speed isn’t one of their strengths. However, with the addition of their Primal Forms, both become more powerful. Kyogre has become much stronger now, with the ability to make it permanently rainy to boost its attacks. Kyogre's power just gets a massive increase thanks to its Primal Form, and Mewtwo likely wouldn’t be able to handle it.

Groudon's Power Over Land Can Help It Defeat Mewtwo

Like Kyogre, Primal Form Makes Groudon Even Stronger

Groudon has power over land, which it could also use to overpower Mewtwo. Just like Kyogre, its Primal Form makes it even stronger and means Mewtwo could have a tough chance of defeating it. In the games, Groudon's ability to make it extremely dry and boost its attacks may make the fight with a Mewtwo a toss-up, but its power in Pokémon lore certainly makes it seem more powerful than Mewtwo.