An isekai is when a character gets sent to another world. This does not happen in Bofuri or SLF. They are not isekai. But virtual reality anime. A better example is Log Horizon.

It doesn't matter nearly so much what it looks like, great story and characterization are king. They make a story engaging. Commentators hold up Frieren and Maomao as examples for many great reasons. Like despite their great knowledge on their specialities, they still don't know everything, and they're not all-powerful.

As much as I enjoy Brent, especially as Data, they really should have recast the role to a young actor mimicking him. Fans did it all the time. We need to face the reality that aging actors aren't as physically capable.

As to a spinoff series, Trek should never have a main character. They should always be ensemble series. They're more interesting when more people matter. And aside from showing Data as the Enterprise E's CO, or showing h talking with Sela about Tasha, I think all that can be done with him has been.

Completely missed the point of Natsuko's character. She's very prideful of her drive to become a prodigy, which isn't helped by everyone telling her she is one. Her arc will likely involve recognizing her limitations, especially as the world's creator, whom she idolizes, continues to challenge her summons with her own abilities. She's also getting more attached to the others.

And as others point out, there is no overwork shown so far. The wall she encountered was her own pride.