Oda has been very clear about not wanting romance between any of the Strawhats. The spinoff can do it, but the main series won't.

Besides, the superior Luffy ship is clearly Boa x Luffy. Luffy and Nami are more like siblings than anything.

Anyone with a brain and common sense and is a diehard fan of both series had to acknowledge that Angel manipulated Buffy every chance that he got, right from the beginning. They were terrible together, though Riley was worse. Spike as a soulless vampire was a better person than either of them, though only after he was forced to stop attacking humans. He fought to keep Dawn safe. His relationship with Buffy was toxic, but not because of his side of it. It was tangled up in violence and rough sex right from the beginning, which led to the unfortunate scene in the bathroom... which directly led to the single most selfless act in the entire series, when a soulless vampire fights through deadly demon trials to get his soul back. Then, half-crazed from the torture his own soul inflicted on him due to the guilt of his crimes he still managed to crawl back to Sunnydale where he was further driven into madness by the First Evil in the form of Buffy. Spike earned his redemption through sweat, blood and tears, whereas Angel was only ever good because he was cursed... and the second his torment ceases, he becomes evil again. Even just thinking he's free of the soul through damn happy pills is enough to make Angel give in to his darker impulses.

Why?

Glory was a great villain, but there's no reason to bring her back. There's no narrative payoff, there. You'd have to invent new material, and in that case, make new characters instead of reusing old ones.