Strange as it might seem, a "daughter" of sorts in the Marvel Universe – and this character, whose powers are derived from genetic material from both iconic heroes, is poised to make a comeback in the publisher's mainstream continuity, and fans want to see one version of "Itsy Bitsy" in particular.

2017's Spider-Man/Deadpool #21 – written by Elliot Kalan, with art by Todd Nauck – featured a variant cover by Ed McGuinness featuring a Venomized version of Itsy Bitsy, and fans have held out hope that this character could make an actual appearance in a story since then. Now, nearly ten years later, the possibility is once more on the table, as Itsy Bitsy is rumored to make a return.

Spider-Man/Deadpool #21 cover, featuring a Venomized version of the character "Itsy Bitsy"

As longtime Spider-Man readers know, Itsy Bitsy's unique physiology and ruthless nature set her apart from typical villains, making her a prime candidate for a prominent role in future Spider-Man comics.

Underrated Spider-Man Villain "Itsy Bitsy" Is Rumored To Be Making A Comeback, And Fans Want Her Venomized This Time

Deadpool & Spider-Man's "Daughter," Explained

Deadpool and Spider-Man's daughter, Itsy Bitsy.

Introduced in Spider-Man/Deadpool #8, Itsy Bitsy is a test subject injected with the combined DNA of Spider-Man and Deadpool. This genetic cocktail granted her a range of incredible powers, including spider abilities and a regenerative healing factor that sures even Deadpool's. Despite her intriguing backstory and potential, Itsy Bitsy has been largely forgotten since her last appearance in 2017. Her return, as teased in issues of Amazing Spider-Man, offers Marvel the perfect chance to explore her depth and complexity.

The symbiote’s ability to amplify its host’s traits would likely bring out even more of Itsy Bitsy’s violent tendencies, creating a true wildcard in Spider-Man’s world.

A Venomized Itsy Bitsy is the stuff of nightmares; already formidable with her enhanced abilities, adding the symbiote’s power elevates her status among the most dangerous villains in the Spider-Man universe. With her spider-like agility, regenerative abilities, and overwhelming strength, a Venomized Itsy Bitsy would likely push Spider-Man to his limits in ways few villains ever have. Adding a symbiote to Itsy Bitsy’s already chaotic mix would push her to new extremes. The symbiote’s ability to amplify its host’s traits would likely bring out even more of Itsy Bitsy’s violent tendencies, creating a true wildcard in Spider-Man’s world.

A Venomized Itsy Bitsy Could Be A Major Complicating Factor In Marvel's Spider-Man Franchise Right Now

Itsy Bitsy’s Return & Her Potential Venomized Form Have Fans Hyped

Marvel villain Itsy Bitsy with Spider-Man and Deadpool caught in a web

With her abilities, Itsy Bitsy is Marvel's symbiotes and their many forms, this seems like an easy way to win over the hearts of longtime fans of Spider-Man and Deadpool.

Spider-Man/Deadpool #21 is available now from Marvel Comics.

  • Spider-Man Swinging in Dodson Comic Art
    Alias
    Peter Parker, Ben Reilly, Otto Octavius, Yu Komori, Kaine Parker, Pavitr Prabhakar, William Braddock, Miles Morales, Kurt Wagner
    Created By
    Stan Lee, Steve Ditko
    Franchise
    Marvel, Spider-Man
    Race
    Human
    First Appearance
    Amazing Fantasy
    Alliance
    Avengers, Fantastic Four, X-Men, Secret Defenders, Future Foundation, Heroes for Hire, Mighty Avengers, New Avengers, Web-Warriors

    Spider-Man is the name given to several individuals who have employed a spider-moniker throughout Marvel Comics. Typically gaining their powers through a bite from a radioactive spider, the different Spider-Man heroes employ super-strength, agility, and intellect while utilizing webbing to swing and tangle up their foes. The most notable of these Spider-Men is Peter Parker, who remains one of the most popular superheroes throughout the world.

  • Deadpool in Comic Cover Art
    Alias
    Wade Wilson
    Created By
    Fabian Nicieza, Rob Liefeld
    POWERS
    Healing factor, regeneration, superhuman strength and agility,
    Franchise
    Marvel
    Birthday
    November 22
    Height
    6'2”

    The merc with the mouth first appeared in an issue of New Mutants in 1990, and since then has gone on to get his own series and a massive cult following. With his incredible powers of healing and regeneration, Deadpool was initially depicted as an X-Men villain but went on to become an anti-hero. After getting his own movie series starting in 2016, the third Deadpool movie finally brings the wisecracking, fourth-wall-breaking character into the Marvel Cinematic Universe.