Acting as a sequel to Enola Holmes (2020), Enola Holmes 2 sees the titular detective and younger sister of Sherlock Holmes pulled into another mystery when a young factory worker asks Enola to help solve her sister's disappearance. Unlike its predecessor, Enola Holmes 2 is not based on the novel series by Nancy Springer. The story instead takes inspiration from the 1888 matchgirls' strike in London. Millie Bobbie Brown reprises her role as Enola, with Henry Cavill and Helena Bonham Carter also reprising their roles as Sherlock and Eudoria Holmes.