A humorous take on the classic Arthur Conan Doyle novels, Holmes and Watson stars Will Ferrell and John C. Reily as the legendary detective duo Sherlock Holmes and Dr. Watson. While in attendance at an event at Buckingham Palace, Holmes and Watson are drawn into a sinister plot by their arch nemesis Professor Moriarty, who intends to kill the Queen. Besides Ferrell and Reily, Ralph Fiennes, Rebecca Hall, Rob Brydon, and Steve Coogan also star.