Darren Aronofsky's Requiem for a Dream follows the lives of four drug addicts as they fall deeper into their addiction and pull their loved ones on a downward spiral along with themselves. The 2000 psychological drama is an adaptation of Hubert Selby Jr.'s eponymous novel and counts with a star-studded cast that includes the likes of Ellen Burstyn, Jared Leto, Jennifer Connelly, Marlon Wayans, Christopher McDonald, and Mark Margolis.