It looks like the Infinity Gauntlet had fused to Thanos' hand at the end of all six Infinity Stones.
Of course, the purpose of the film, which has its plot continuing in this year's left him permanently scarred.
Related: Thanos' Role In Avengers: Endgame Will Be Marvel's Biggest Surprise
While many people believed that Thanos' quest would emotionally scar him after being forced to (not to mention choosing to) sacrifice Gamora, the one person who he loved most in the universe, it turns out that the snap also left him physically scarred. That much is clear in Infinity War, when viewers can see the Infinity Gauntlet burning on his hand and seemingly on the rest of his arm, too. But the scarring doesn't appear to end there, as it seems the Infinity Gauntlet is now fused to his hand.
In the takes place mere moments after Infinity War, but since he's already accomplished his mission, there's no reason for him to still be wearing the glove - unless, of course, using all six Infinity Stones at once burned the Infinity Gauntlet to his hand.
While this didn't happen in the Thanos' snap), then this will make things considerably difficult for the Avengers as they attempt to defeat Thanos once and for all.