The latest Spider-Man: Brand New Day rumors claim that not only will Mark Ruffalo appear in the movie, but the Hulk will be one of its villains. If that were to be accurate, then I know the perfect way for how it could work in the street-level setting the MCU seems to be going for with the film. The next Spider-Man movie could be about a gang war, with the Hulk turning into his Joe Fixit persona from the comics, perhaps after being influenced by the film's true main villain. I hope we get official story details soon.