Grey’s Anatomy is going into its 21st season and has been going strong for almost 20 years. In that time, the series has also killed off numerous characters (major, ing, and minor) in storylines that have brought viewers to tears. Almost every Grey’s Anatomy death hit me hard, but the saddest death for me was Lexie’s because she was so young and Meredith never got to say goodbye. It was made even more devastating by the love of her life, Mark, dying shortly after.