After she made the character perhaps the most popular in the DC Extended Universe, Margot Robbie is expected to return as Harley Quinn whenever James Gunn's new DC Universe decides to use the character. However, if Robbie does not come back, and the actor has already talked about how she would love to make Harley a role that es through many talented actors over the years, then I think the DCU has some great choices to replace her. My favorite picks would be Victoria Pedretti, who stunned as an unpredictable serial killer in <em>You</em>, and Emma Stone, who can nail Harley's energy.