The events that take place onsurprising lack of crossovers from Vampire Diaries' fan favorites with the exceptions of Matt Donovan, Jeremy Gilbert, and Kai Parker. Most conspicuously absent are Caroline Salvatore (née Forbes), Bonnie Bennett, and Damon and Elena.
On the final episode of The Vampire Diaries, the main characters mortal Stefan sacrifices himself to ensure Katherine perishes in the flames.
Before Stefan dies, he injects his brother with the cure. The Originals season 5, episode 12 "The Tale of Two Wolves," a window that reads "Elena Salvatore, M.D." confirms Elena follows in her father's footsteps and becomes the town doctor.
The murky details surrounding the couples' supernatural-free existence come more into focus On Legacies season 1, episode 10 "There's a World Where Your Dreams Come True." Elena have kids of their own that they need to take care of."
Lizzie's second wish of the Salvatore School not existing at all results in her and Josie attending Mystic Falls High School, along with Damon and Elena's daughter, Stefanie Salvatore. Josie instructs Lizzie to steal their dad's watch which was a gift from Stefanie Salvatore's father. In both alternate dimensions, Damon and Elena have at least one child and are alive and well - if not well off - living in Mystic Falls. But how reliable is this information? It's nice to get even the slightest glimpse into revealed in future episodes.