One of the most intriguing elements of House M.D. is the titular character's relationship with Dr.Lisa Cuddy, but unfortunately, the two don't end up together in the end. House M.D., more commonly referred to as House, is a popular medical drama that ran for eight seasons and follows the erratic and antisocial Dr. Gregory House as he approaches some of the biggest medical mysteries like a detective would. The puzzling cases that House tackles, coupled with his complex interactions with fellow characters like Cuddy, is what kept the show interesting for so many seasons.

The relationship between him and Cuddy captivated audiences since the beginning of the show. It was especially fascinating to see House attempt to put his destructive tendencies behind him to be able to have a healthy and happy relationship with his fellow doctor. Their relationship history was complicated and filled with many ups and downs, with the two not ending up together in the end despite sharing great moments in some of the best House episodes.

Cuddy Breaks Up With House In House Season 7, Episode 15

House confirmed Cuddy and House would be no more towards the end of season 7. In season 7, episode 15, "Bombshells", it is suspected that Cuddy has cancer, and she learns that House took Vidocin in order to be able to her during this time. This leads Cuddy to confront House about relapsing and ultimately end their relationship.

Cuddy and House's relationship had been rocky in the past, with a number of makeups and breakups. This led audiences to be unsure as to whether or not this breakup would stick. It did, however, mark the absolute end of their romance. By this point, Cuddy could no longer continue to be with someone who is as unpredictable and erratic as House. His drug addiction struggles and manipulation were too much for her, and she was unwilling to put up with it any longer.

Cuddy’s Actress Lisa Edelstein Exited House Before Season 8

Perhaps Cuddy and House could have worked through their serious issues and gotten back together later on in the show, but this was not an option because Cuddy's actress, Lisa Edelstein, exited the show before its end. House after most of the actors' contracts ended with season 7. In order to save money moving forward, the network wanted to issue pay cuts to their actors. Edelstein was reportedly unwilling to accept this and ultimately left the show.

Considering she won a People's Choice Award for her performance in House, it is no surprise that she was able to book a number of other roles after leaving. Edelstein went on to appear in shows such as The Good Wife, Castle, The Good Doctor, and The Kominsky Method, among others. Edelstein has also shared that she has no regrets about not returning to the finale and shared with Digital Spy that she doesn't think Cuddy and House were meant to ever get a "happily ever after".